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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified E

The INK4a-ARF locus is comprised of two tumor suppressors, p16INK4a and p14ARF. These two proteins are encoded through differential splicing of alternative first exons. The p16INK4a (exon 1alpha) protein inhibits the cyclin D-dependent kinases (CDK) that control the phosphorylation of the Rb protein and cell proliferation. The p14ARF gene product complexes with the MDM2 protein within the nucleus, thus modulating the activity of the p53 protein. P14ARF is a potent tumor suppressor in the presence of wild-type p53, while mutant p53 substantially reduces growth inhibition by p14ARF. (1-3)
Catalog #	A3330-02A
Positive control	BT549 cells
CAS Number	n/a
Clone Type	Polyclonal
Host	Rabbit
Source	Human
Concentration	~2mg/ml
Form	Supplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
Purity	Purified by affinity chromatography.
Immunogen	Synthetic peptide from the human sequence of p14ARF.
Specificity	Specific for human p14ARF.
Important Note	This product is intended for research use only, not for use in human, therapeutic or diagnostic applications.