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You are here:Home » Antibodies » Abs to Cancer Markers » Anti -ARF, p14 (p14ARF )

Anti -ARF, p14 (p14ARF )

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IF
The INK4a-ARF locus is comprised of two tumor suppressors, p16INK4a and p14ARF. These two proteins are encoded through differential splicing of alternative first exons. The p16INK4a (exon 1alpha) protein inhibits the cyclin D-dependent kinases (CDK) that control the phosphorylation of the Rb protein and cell proliferation. The p14ARF gene product complexes with the MDM2 protein within the nucleus, thus modulating the activity of the p53 protein. P14ARF is a potent tumor suppressor in the presence of wild-type p53, while mutant p53 substantially reduces growth inhibition by p14ARF.
Catalog #A3330-02F
Positive Control BT549 or HeLa whole cell extracts
ApplicationsSuitable for use in Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormAs reported
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide to human p14ARF (C-terminal sequence).
SpecificityThis antibody is specific for p14ARF. Species Crossreactivity: This antibody reacts with human p14ARF. Other species untested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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