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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -ARHGEF4 (APC-stimulated Guanine Nucleotide Exchange Factor, Asef, GEF4, GEF-4, KIAA1112, Rho Guanine Nucleotide Exchange Factor (GEF) 4, Rho Guanine Nucleotide Exchange Factor 4, STM6)

Anti -ARHGEF4 (APC-stimulated Guanine Nucleotide Exchange Factor, Asef, GEF4, GEF-4,
KIAA1112, Rho Guanine Nucleotide Exchange Factor (GEF) 4, Rho Guanine Nucleotide Exchange
Factor 4, STM6)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through Gucleotide exchange protein coupled receptors. Acts as guanine nucleotide exchange factor (GEF) for RhoA and RAC1 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. This protein is similar to rat collybistin protein. Alternative splicing of the gene generates two transcript variants which encode different isoforms.
Catalog #A3570-66M
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000.
Western Blot: 2-4ug/ml. ~ 80kD band observed in Human Brain lysates (calculated MW of 79.1kD according to NP_056135 and 76.4kD according to 127462).
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris-saline, pH 7.2. 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide PWEEPAGEKPSCS, representing the N-Terminus of the human protein (residues 2-13), according to NP_056135; NP_127462.
SpecificitySpecies Crossreactivity: Reacts with Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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