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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -ARHGEF4 (Rho Guanine Nucleotide Exchange Factor 4, APC-stimulated Guanine Nucleotide Exchange Factor 1, Asef, Asef1, KIAA1112)

Anti -ARHGEF4 (Rho Guanine Nucleotide Exchange Factor 4, APC-stimulated Guanine Nucleotide
Exchange Factor 1, Asef, Asef1, KIAA1112)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through Gucleotide exchange protein coupled receptors. Acts as guanine nucleotide exchange factor (GEF) for RhoA and RAC1 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. This protein is similar to rat collybistin protein. Alternative splicing of the gene generates two transcript variants which encode different isoforms.
Catalog #A3570-66M2
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Western Blot: 2-4ug/ml, observed in human brain lysates and in transfected HEK293 on ~80kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to PWEEPAGEKPSCS, from human ARHGEF4, at N-terminal (NP_056135.2, NP_127462.1).
SpecificityRecognizes human ARHGEF4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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