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You are here:Home » Antibodies » Abs to Protein Kinases » Anti -ARK5 (NUAK Family SNF1-like Kinase 1, AMPK-related Protein Kinase 5, Omphalocele Kinase 1, KIAA0537, NUAK1, OMPHK1)

Anti -ARK5 (NUAK Family SNF1-like Kinase 1, AMPK-related Protein Kinase 5, Omphalocele
Kinase 1, KIAA0537, NUAK1, OMPHK1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
AMPK-related kinase 5, also known as NUAK1, is a 74kD intracellular Ser/Thr kinase that promotes cell survival during nutrient deprivation and TNF family ligand-induced apoptosis. ARK5 is activated by Akt, NDR2, and LKB1-mediated phosphorylation at multiple serine and threonine residues. It inhibits the activation of Caspase-6, Caspase-8, and myosin phosphatases but promotes the activation of MMP2 and MMP9. ARK5 overexpression in several cancers contributes to increased tumor progression and aggressiveness. ARK5 contains one catalytic domain aa65-306 and a short isoform of the human protein is prematurely tuncated within this domain. Within aa311-462, human ARK5 shares 88% and 85% aa sequence identity with mouse and rat ARK5.
Catalog #A3570-79C
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No12K12
HostMouse
SourceHuman
Concentration~0.5mg/ml after reconstitution
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to aa311-462 from human ARK5 expressed in E. coli.
SpecificityRecognizes human ARK5. Species Crossreactivity: Mouse and rat. Does not react with recombinant human SNARK.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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