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You are here:Home » Antibodies » Abs to Arrestin » Anti -Arrestin 1, beta (ARRB1, ARB1, ARR1)

Anti -Arrestin 1, beta (ARRB1, ARB1, ARR1)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E IH
The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (b-Arrestin 1), Arrestin 3 (b-Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, b-Arrestins 1 and 2 are ubiquitously expressed, and were initially described as negative regulators of G protein-coupled receptor (GPCR) signaling. More recently, b-Arrestins have been determined to serve as scaffolds for various signaling pathways, including the MAPK cascades activating ERK2, p38a, and JNK3. These b-Arrestin scaffolds tie together the appropriate kinases in series, forming a discreet signaling module that localizes components to specific subcellular environments and facilitates greater kinase activation.
Catalog #A3576-98
Applications Suitable for use in ELISA, Immunohistochemistry
Recommended DilutionImmunohistochemistry: 3-10ug/ml with the appropriate secondary reagents to detect b-Arrestin 1 in paraffin-embedded sections of normal human spleen and human colon cancer.
Optimal dilutions should be determined by the individual laboratory.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~3-10ug/ml
FormSupplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 1ml sterile 40-50% glycerol, PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenE. coli-derived full-length recombinant human b-Arrestin 1.
SpecificityRecognizes human b-Arrestin 1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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