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You are here:Home » Antibodies » Abs to Arrestin » Anti -ARRB2 (Beta-arrestin-2, Arrestin beta-2, ARB2, ARR2)

Anti -ARRB2 (Beta-arrestin-2, Arrestin beta-2, ARB2, ARR2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
Beta-arrestin-2 or ARRB2 is a 409aa adaptor protein belonging to the arrestin family with an N- arrestin domain and a C-arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta-adrenergic receptor A function, thus enhancing beta2AR receptor-mediated nuclear translocation of ERK. It binds to phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. ARRB2 is widely expressed in most tissues, particularly neuronal tissues and spleen.
Catalog #A3577-02D
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum.
ImmunogenSynthetic peptide corresponding to aa281-298 DNREKRGLALDGKLKHED of human ARRB2.
SpecificityRecognizes human ARRB2. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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