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You are here:Home » Antibodies » Abs to Apoptosis » Anti -ARTS (Apoptosis Related Protein in TGF beta Signaling Pathway)

Anti -ARTS (Apoptosis Related Protein in TGF beta Signaling Pathway)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identi ed recently and designated ARTS for apoptosis related protein in TGF-b signaling pathway (1). ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene (1-4) is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-b and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.
Catalog #A3595
Applications Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution Western Blot: 0.5-2ug/ml; Optimal dilutions to be determined by the researcher.
Positive Control Human lung, kidney and spleen tissue lysates
Storage and Stability May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenRaised against a synthetic peptide (KRFLEDTTDDGE) corresponding to amino acids 3 to 14 of human ARTS (1).
SpecificityRecognizes a band at 32kD.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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