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Anti -ASC (TMS1, Target of Methylation-induced Silencing) (CT)
Anti -ASC (TMS1, Target of Methylation-induced Silencing) (CT)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| TMS1, also known as apoptosis-associated speck-like protein containing a CARD (ASC). It was first identified as a cytosolic soluble protein that forms insoluble aggregates and promotes caspase-mediated apoptosis. The proapoptotic activity is mediated predominantly though the activation of caspase 9. It may also be a component of the inflammasome, where it associates with caspase 1, CARD8 and NALP2 to activate proinflammatory caspases. TMS1 is widely expressed in human tissue. | | | | | | Applications: | | | Suitable for use in Western Blot. Other applications not tested. | | | Catalog # | A3598-05H | | Recommended Dilution | Western Blot: 1ug/ml ~25kD in HL60 cell lysates. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | A peptide corresponding to aa182-195 of human TMS1. | | Specificity | Recognizes human TMS1, also known as apoptosis-associated speck-like protein containing a CARD (ASC). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | ASC |
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