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You are here:Home » Molecular Biology » MB-Apoptosis » ASC, Blocking Peptide (TMS1, Target of Methylation-induced Silencing)

ASC, Blocking Peptide (TMS1, Target of Methylation-induced Silencing)

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Specifications

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1 (13). Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells (3,4). Overexpression of ASC/TMS1 induced DNA fragmentation (4). ASC/TMS1 is expressed in a variety of human and mouse tissues (1, 2)
Catalog #A3598P
ApplicationsSuitable for use in ELISA, Western Blotting. Other applications not tested.
Positive Control HL60 whole cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C or colder. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceSynthetic peptide
PurityPurified 60-70%
Concentration0.2mg/ml
FormSupplied as a lyophilized powder.
SpecificityRecognizes human ASC (TMS1). An approximate 25kD band can be detected. Species crossreactivity: Other species not tested.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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