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ASC, Blocking Peptide (TMS1, Target of Methylation-induced Silencing)
ASC, Blocking Peptide (TMS1, Target of Methylation-induced Silencing)
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| Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1 (1–3). Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells (3,4). Overexpression of ASC/TMS1 induced DNA fragmentation (4). ASC/TMS1 is expressed in a variety of human and mouse tissues (1, 2) | | | Catalog # | A3598P | | Applications | Suitable for use in ELISA, Western Blotting. Other applications not tested. | | Positive Control | HL60 whole cell lysate | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C or colder. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Source | Synthetic peptide | | Purity | Purified 60-70% | | Concentration | 0.2mg/ml | | Form | Supplied as a lyophilized powder. | | Specificity | Recognizes human ASC (TMS1). An approximate 25kD band can be detected. Species crossreactivity: Other species not tested. | | | Important Note | This product is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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