Anti -ASCL2 (Achaete-Scute Complex Homolog 2 (Drosophila), Achaete-scute Homolog 2, ASH2,
ASH-2, bHLHa45, BHLHA45, Class A Basic Helix-loop-helix Protein 45, hASH2, HASH2, Mash2,
MASH2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP IC |
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| Achaete Scute homolog 2 (also known as mammalian aschaete-scute homolog 2 or Mash2) is a nuclear protein expressed specifically in the extravillous trophoblasts of developing placenta. Placental development involves control by the basic helix-loop-helix transcription factor Achaete Scute homolog 2, which may regulate HIF (hypoxia) in the formation of spongiotrophoblasts. Targeted mutagenesis of Achaete Scute homolog 2 yielded loss of function results in embryonic lethality at midgestation due to placental failure associated with a lack of spongiotrophoblasts and reduced labyrinthine trophoblast layers. In addition to healthy placental development, Achaete Scute proteins may also be involved in the determination of neuronal precursors in the central and peripheral nervous systems. Achaete Scute homolog 2 has also been implicated as a controller of intestinal stem cell fate and is essential for the maintenance of adult intestinal stem cells. | | | Catalog # | A3619-81 | | Applications | Suitable for use in Western Blot, Immunoprecipitation(ChIP) and Immunocytochemistry. Other applications not tested. | | Recommended Dilutions | Western Blot: 1ug/mL detected ASCL2 in 10ug of human placenta tissue lysate. | | Optimal dilutions to be determined by the researcher. | | Recommended Secondary Antibodies | I1904-06C: IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo | | I1904-06H: IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b | | Clone No | 10F628 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 0.1M Tris-Glycine pH 7.4, 150mm sodium chloride, 0.05% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Recombinant protein corresponding to C-terminus of human Achaete Scute homolog 2 (His-tagged). | | (Accession #NP_005161.1) | | Specificity | Recognizes human Achaete Scute homolog 2 at ~20kD. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Achaete-Scute Complex (Drosophila) Homolog-like 2 |
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Download Specifications for Anti -ASCL2 (Achaete-Scute Complex Homolog 2 (Drosophila), Achaete-scute Homolog 2, ASH2, ASH-2, bHLHa45, BHLHA45, Class A Basic Helix-loop-helix Protein 45, hASH2, HASH2, Mash2, MASH2) |
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