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You are here:Home » Biochemicals » Biochem-Antibiotics » Ascochlorin (Antibiotic LL-Z 1272 gamma)

Ascochlorin (Antibiotic LL-Z 1272 gamma)


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The antitumour fungal metabolite ascochlorin specifically inhibits matrix metalloproteinase-9 (MMP9) activity through suppression of activator protein-1 (AP-1) dependent induction of MMP-9 gene expression. Via AP-1 suppression ascochlorin selectively kills MX-1 cells, a human breast cancer cell line lacking estrogen receptors. Ascochlorin also shows activity against Newcastle disease and herpes simplex viruses.
Catalog #A3690
Purity >95% by HPLC
Solubility Soluble in ethanol, methanol, DMF or DMSO.
CAS Number26166-39-2
Molecular FormulaC23H29ClO4
Molecular Weight404.9
SourceAcremonium sp.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAntibiotic LL-Z 1272 gamma

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