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Ascochlorin (Antibiotic LL-Z 1272 gamma)
Ascochlorin (Antibiotic LL-Z 1272 gamma)
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| The antitumour fungal metabolite ascochlorin specifically inhibits matrix metalloproteinase-9 (MMP9) activity through suppression of activator protein-1 (AP-1) dependent induction of MMP-9 gene expression. Via AP-1 suppression ascochlorin selectively kills MX-1 cells, a human breast cancer cell line lacking estrogen receptors. Ascochlorin also shows activity against Newcastle disease and herpes simplex viruses. | | | Catalog # | A3690 | | Purity | >95% by HPLC | | Solubility | Soluble in ethanol, methanol, DMF or DMSO. | | CAS Number | 26166-39-2 | | Molecular Formula | C23H29ClO4 | | Molecular Weight | 404.9 | | Source | Acremonium sp. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Antibiotic LL-Z 1272 gamma |
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