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You are here:Home » Antibodies » Abs to Receptors » Anti -ASC2 (Activating Signal Cointegrator-2, NCOA6, NCOA-6, Nuclear Receptor Coactivator 6, PRIP, Peroximome-Proliferator-Activated Receptor Interacting Protein, AIB3, Pyrin Domain Containing 1, POP1)

Anti -ASC2 (Activating Signal Cointegrator-2, NCOA6, NCOA-6, Nuclear Receptor Coactivator
6, PRIP, Peroximome-Proliferator-Activated Receptor Interacting Protein, AIB3, Pyrin
Domain Containing 1, POP1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IP
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.
Catalog #A3774-10C
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormAs reported
PuritySerum
ImmunogenA synthetic peptide that maps to a region between residues 2000 and the C-terminus (residue 2063) of human Activating Signal Cointegrator-2 using the numbering given in Swiss-Prot entry Q14686 (GeneID 23054).
SpecificitySpecific for human ASC2 protein. Species Crossreactivity: Human. Other species not tested. Reactivity with mouse ASC2 is expected owing to conservation of sequence between this ortholog and human ASC2 at the site to which the epitope maps.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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