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You are here:Home » Antibodies » Abs to Protein Kinases » Anti -ASK1, CT (Mitogen-activated Protein Kinase Kinase Kinase 5, Apoptosis Signal-regulating Kinase 1, ASK-1, MAPK/ERK Kinase Kinase 5, MEK Kinase 5, MEKK 5, MAP3K5, MAPKKK5, MEKK5)

Anti -ASK1, CT (Mitogen-activated Protein Kinase Kinase Kinase 5, Apoptosis
Signal-regulating Kinase 1, ASK-1, MAPK/ERK Kinase Kinase 5, MEK Kinase 5, MEKK 5, MAP3K5,
MAPKKK5, MEKK5)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH IC
MEKK5, also known as ASK1 for apoptosis signal-regulating kinase-1, is a MAP3K type protein kinase and a member of the JNK and p38 MAP kinase signaling pathways. The protein contains a centrally located protein kinase domain, a N-terminal extension that includes binding regions for the Fas-associated adapter protein Daxx and the redox-sensing enzyme thioredoxin, and a C-terminal extension that binds members of the TNFR-associated factor (TRAF) family. MEKK5 regulates the JNK cascade by phosphorylating MKK4/MAP2K4 and p38 cascades by phosphorylating MEK3/MAP2K3 and MKK6/MAP2K6. MEKK5 has been shown to be activated by oxidant stress, tumor necrosis factor (TNF) via TRAF2 and Fas via Daxx. MEKK5 also can be activated by Fas-Daxx in a kinase-independent apoptotic pathway.
Catalog #A3794-01C
ApplicationsSuitable for use in ELISA, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 16aa from near the C-terminus of human ASK1 conjugated to KLH.
SpecificityRecognizes human ASK1. Species sequence homology: Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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