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You are here:Home » Antibodies » Abs to Protein Kinases » Anti -ASK1 (Mitogen-activated Protein Kinase Kinase Kinase 5, Apoptosis Signal-regulating Kinase 1, ASK-1, MAPK/ERK Kinase Kinase 5, MEK Kinase 5, MEKK 5, MAP3K5, MAPKKK5, MEKK5)

Anti -ASK1 (Mitogen-activated Protein Kinase Kinase Kinase 5, Apoptosis Signal-regulating
Kinase 1, ASK-1, MAPK/ERK Kinase Kinase 5, MEK Kinase 5, MEKK 5, MAP3K5, MAPKKK5, MEKK5)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IF
ASK1 (Apoptosis Signal-regulating Kinase 1) activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activate c-Jun N-terminal Kinase (JNK) and p38 MAP Kinase. ASK1 is activated by TNFR and Fas through the interaction with members of the TRAF Family and the Fas-associated protein Daxx. Overexpression of ASK1 induces apoptosis. However, a catalytically inactive form of ASK1 has been shown to inhibit TNF-a induced apoptosis.
Catalog #A3794-01E
ApplicationsSuitable for use in Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1-4ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 1% BSA, 0.02% sodium azide, 50% glycerol.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa1359 of human ASK1.
SpecificityRecognizes human ASK1/MAPKKK5 at ~155kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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