Anti -ASK1, CT (Apoptosis Signal-regulating Kinase 1, ASK-1, Mitogen-activated Protein
Kinase Kinase Kinase 5, MAP3K5, MAPKKK5, MAPK/ERK Kinase Kinase 5, MEK Kinase 5, MEKK 5,
MEKK5)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
B |
|
| Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activate c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. Overexpression of ASK1 induces apoptotic cell death, and a catalytically inactive form of ASK1 inhibits TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues. | | | Catalog # | A3795 | | Applications | Suitable for use in Western Blot Other applications have not been tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Optimal dilutions to be determined by the researcher. | | Positive Control | SW1353 whole-cell lysate | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified IgG | | Immunogen | Raised against a peptide corresponding to amino acids 1356 to 1375 of human ASK1. This sequence is different from that of mouse by last two amino acids. | | Specificity | Recognizes human ASK1. A 155kD band can be detected. | | | Important Note | This product is intended for research use only, not for use in human, therapeutic or diagnostic applications. | | Alternate names | EC=2.7.11.25 |
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