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You are here:Home » Antibodies » Abs to Enzymes, Synthetase » Anti -Asparagine Synthetase (AS, Cell Cycle Control Protein TS11, Glutamine Dependent Asparagine Synthetase 3, Glutamine Hydrolyzing, TS11)

Anti -Asparagine Synthetase (AS, Cell Cycle Control Protein TS11, Glutamine Dependent
Asparagine Synthetase 3, Glutamine Hydrolyzing, TS11)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IH IC
Asparagine synthetase (AS) is a housekeeping enzyme responsible for the production of asparagine from aspartate and glutamine. Most mammalian cells express AS and regulate the level of activity in response to the concentration of asparagine in the medium. Certain tumor cells, in contrast, exhibit little or no AS activity and rely on the surrounding medium as a source of exogenous asparagines. Therefore tumor cells may be selectively killed by a chemotherapeutic drug using asparaginase. This approach has been exploited in the treatment of certain cancers like childhood acute lymphoblastic leukemia.
Catalog #A3825-12
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1:500-1:2000
Immunohistochemistry (Paraffin): 1:50
Immunocytochemistry (IF): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlsK562 cell lysate, human breast carcinoma tissue and human muscle tissue
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patent, No 5,675,063, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No6k30
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in PBS, 0.05% BSA, 0.01% sodium azide, 50% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues on the C-terminus of human Asparagine Synthetase.
SpecificityRecognizes human Asparagine Synthetase at ~60kD.
Species CrossreactivityRat and mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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