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You are here:Home » Antibodies » Abs to Apoptosis » Anti -ASPP1 (ASPP-1, Apoptosis-Stimulated Protein of p53 Protein 1, PPP1R13B, Protein Phosphatase 1, Regulatory Subunit 13Bp53BP1-like, p85)

Anti -ASPP1 (ASPP-1, Apoptosis-Stimulated Protein of p53 Protein 1, PPP1R13B, Protein
Phosphatase 1, Regulatory Subunit 13Bp53BP1-like, p85)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
The ASPP family members ASPP1, ASPP2, act as potent activators of p53. A third member of the family, iASPP, has an inhibitory effect on apoptosis. The three members of ASPP family all bind p53 via their C-terminus, which contains a proline-rich region, four ankyrin repeats and an SH3 domain. Expression of ASPP1 and ASPP2 is frequently downregulated in human breast tumors expressing wild-type p53. ASPP1 may also play a role in vascular development.
Catalog #A3883-50
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormTris-citrate/phosphate buffer, pH 7 to 8
PurityPurified by immunoaffinity chromatography.
ImmunogenThe epitope recognized maps to a region between residue 50 and 100 of human Apoptosis-Stimulated Protein of p53, 1 using the numbering given in entry NP_056131.1 (GeneID 23368).
SpecificityThis antibody is specific to the human ASPP1 protein. Species Crossreactivity: Human. Other species have not been tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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