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You are here:Home » Antibodies » Antibodies-Transport Proteins » Anti -ATP7b (PWD, WC1, WND)

Anti -ATP7b (PWD, WC1, WND)


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Clone Host Grade Applications
Polyclonal Rabbit Purified B IC
ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene; A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140kD is found in mitochondria. Mutations in the ATP7b gene can cause Wilsonís disease, an inherited disorder causing copper poisoning in the brain and liver.
Catalog #A3999-82B
ApplicationsSuitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000. Recognizes a band at 165kD, representing ATP7b protein. Also recognizes a band at ~220kD.
Immunocytochemistry: 1:500 using ovarian carcinoma cells
Optimal dilutions to be determined by the researcher.
Positive Control HuH7 hepatocarcinoma cell extracts
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
FormSupplied as a liquid containing 0.1% sodium azide
ImmunogenSynthetic peptide made to an internal sequence nearer the C-terminus of human ATP7b
SpecificityRecognizes human ATPb7. Results on mouse appear to be negative.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesATPase, Copper Transporting, beta Polypeptide

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