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You are here:Home » Molecular Biology » MB-Enzymes, ATPase » ATP6E (V-ATPase, Subunit E, H+ Transporting, Lysosomal) Recombinant, Human

ATP6E (V-ATPase, Subunit E, H+ Transporting, Lysosomal) Recombinant, Human

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Specifications

This protein is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain E subunit proteins and is found ubiquitously.
Catalog #A4000-51D
Species Homo sapiens
Source E. coli
Primary Sequence (aa) 226
Domain (aa) Full-length
Tag/Fusion Partner T7 Tag
Applications Suitable for use in ELISA as an Antigen, Ligand, or Assay Standard. Other applications not tested.
Quality Control SDS-PAGE Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.
Important note This recombinant enzyme has NOT been tested with regard to biological activity.
SourceE. coli
PurityHighly purified
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2. No preservative added.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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