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You are here:Home » Antibodies » Abs to Enzymes, ATPase » Anti -ATPase alpha 1, Na, K

Anti -ATPase alpha 1, Na, K

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IP IH
Na+/K+ ATPase a-1 is a human gene and functions to maintain Na+ and K+ across the cell membrane which is important for osmoregulation. It is a component of (Na+/K+) ATPase, a transporter that catalyzes the hydrolysis of ATP and transports sodium and potassium ions across the plasma membrane. It also partners with Src and other signaling proteins. Binding of ouabain and other cardiotonic steroids to the (Na+/K+) ATPase activates Src, resulting in the assembly and activation of multiple signaling cascades. Binding of ouabain also induces a positive inotropic effect. Diseases associated with ATPase are Thyrotoxic periodic paralysis and hyperthyroidism.
Catalog #A4000-53
ApplicationsSuitable for use in Immunoprecipitation and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionsImmunoprecipitation: 10ug immunoprecipates ATPase from 500ug of rat brain microsomal lysates.
Immunohistochemistry: 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenGST-tagged ATPase. Cellular Localization: Cytoplasmic domain.
SpecificityRecognizes rat ATPase a-1 subunit isoform at Mr of 110kD. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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