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You are here:Home » Antibodies » Abs to Enzymes, Synthase » Anti -ATP-Citrate Lyase, phosphorylated (Thr447/Ser451) (ACL, ATP Citrate (pro-S) Lyase, ATP Citrate Synthase, Citrate Cleavage Enzyme, EC 2.3.3.8)

Anti -ATP-Citrate Lyase, phosphorylated (Thr447/Ser451) (ACL, ATP Citrate (pro-S) Lyase,
ATP Citrate Synthase, Citrate Cleavage Enzyme, EC 2.3.3.8)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IC
ATP citrate lyase (ACLY), also known as ATP citrate synthase, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of four identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. One of these products, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. NDPK has been found to phosphorylate ACLY and insulin to increase phosphorylation of ACLY (2).
Catalog #A4001-35D
ApplicationsSuitable for use in Immunocytochemistry, Western Blotting. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Immunocytochemistry: 1: 100 250
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9E153
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
PuritySupernatant
ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Thr447 and Ser451 of human ATP-citrate (pro-S) lyase
SpecificityRecognizes human ATP-Citrate Lyase when phosphorylated on
Threonine 447 and Serine 451.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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