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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified B IH

Ataxin-1 is a member of the ATXN1 protein family and contains a single AXH domain. It is a neurodegenerative disorder protein thought to have a role in the metabolism of RNA as it has been shown to localize to the RNA and transcription dependent inclusions within the nucleus. A mutation of Ataxin-1 is the cause of spinocerebellar ataxia type-1 (SCA1), a progressive, neurodegenerative disease that is autosomal dominant and primarily affects the Purjinke cells found in brain stem neuronal populations and the cerebellum. Expression of Ataxin-1 is almost ubiquitous, except in the brain where it is isolated to populations of neurons.
Catalog #	A4159-04G
Applications	Suitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
	Immunohistochemistry: 1:500 dilution detects Ataxin-1 in rat cerebral cortex tissue.
	Optimal dilutions to be determined by the researcher.
Positive Control	Rat hippocampus tissue
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	N/A
Clone Type	Monoclonal
Isotype	IgG2b,k
Clone No	11C231
Host	Mouse
Source	Mouse
Concentration	~1mg/ml
Form	Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Purity	Purified by Protein G affinity chromatography.
Immunogen	Linear peptide corresponding to mouse Ataxin-1. Cellular Localization
Specificity	Recognizes mouse Ataxin-1. Species crossreactivity: rat
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.