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You are here:Home » Molecular Biology » MB-Ataxin » ATX3, Recombinant, Human (ATXN3, AT3, ATX3, Ataxin 3, JOS, Machado-Joseph disease protein 1, MJD, MJD1, SCA3, Spinocerebellar ataxia type 3 protein)

ATX3, Recombinant, Human (ATXN3, AT3, ATX3, Ataxin 3, JOS, Machado-Joseph disease protein
1, MJD, MJD1, SCA3, Spinocerebellar ataxia type 3 protein)

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Specifications

Ataxin 3 is also known as Machado-Joseph disease protein 1. Machado–Joseph disease is one of several hereditary autosomal dominant neurodegenerative disorders. This protein contains trinucleotide CAG repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. Ataxin 3 interacts with the major histone acetyltransferases cAMP-response-element binding protein (CREB)-binding protein, p300, and p300/CREB-binding protein-associated factor and inhibits transcription by these coactivators. Also, ataxin-3 is a proteasome-associated factor that mediates the degradation of ubiquitinated proteins.
Recombinant human Ataxin-3 was expressed in E.coli and purified by using conventional chromatography.
Catalog #A4159-08
Molecular Weight42.4 kD(370aa)
AA SequenceMESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM
IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RVLEANDGSG MLDEDEEDLQ RALALSRQEI DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ QQQQQQQQQQ QQQQGDLSGQ SSHPCERPAT SSGALGSDLG DAMSEEDMLQ AAVTMSLETV
RNDLKTEGKK.
Storage and StabilityAliquot to avoid repeated freezing and thawing. Store at -20°C/70°C. Aliquots are stable for 6 months at -20°C./-70°C For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight42.4kD
SourceE. coli
Purity~90% by SDS- PAGE. Endotoxin: 1EU/1ug (LAL)
ConcentrationAs reported
FormSupplied as a liquid in 20 mM Tris-HCl buffer, pH 7.5, 2mM DTT, 50mM sodium chloride, 10% glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesATX3, MJD, MJD1, SCA3, ATXN3, JOS, ATXN3


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