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You are here:Home » Antibodies » Abs to Ataxin » Anti -Ataxin 3 (Ataxin-3, Machado-Joseph Disease Protein 1, Spinocerebellar Ataxia Type 3 Protein, ATXN3, ATX3, MJD, MJD1, SCA3)

Anti -Ataxin 3 (Ataxin-3, Machado-Joseph Disease Protein 1, Spinocerebellar Ataxia Type 3
Protein, ATXN3, ATX3, MJD, MJD1, SCA3)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.
Catalog #A4159-09
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No11E21
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenFull length recombinant corresponding to ATX-3.
SpecificityRecognizes human ATX-3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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