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Abs to Apoptosis, Caspase
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Anti -Aven, NT (Apoptosis Caspase Activation Inhibitor, Cell Death Regulator Aven, PDCD12)
Anti -Aven, NT (Apoptosis Caspase Activation Inhibitor, Cell Death Regulator Aven, PDCD12)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases suc h as cancer (reviewed in 1). Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9 (2). It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients (3). Despite its predicted molecular weight, Aven often migrates at 55kD in SDS-PAGE. | | | Catalog # | A4445-11 | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-1ug/ml. See A4445-11A for control peptide. | | Optimal dilutions to be determined by the researcher. | | Positive Control | Raji cell lysate | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | 18 amino acid peptide from near the amino terminus of human Aven (GenBank accession no. NP_065104) | | Specificity | Recognizes human Aven. Species Crossreactivity: Mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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