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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -Aven (Apoptosis Caspase Activation Inhibitor, Cell Death Regulator Aven, PDCD12)

Anti -Aven (Apoptosis Caspase Activation Inhibitor, Cell Death Regulator Aven, PDCD12)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B FC IF
The Bcl-2 family regulates apoptosis in response to a wide range of stimuli through control of mitochondrial cytochrome c release and caspase activation. Cytosolic Apaf-1 forms a complex with caspase-9 in the presence of cytochrome c and dATP, ultimately leading to caspase-9 activation and subsequent activation of caspase-3. A large number of proteins have been found to interact with Bcl-2 and other family members that have been shown to help regulate apoptosis. Aven was identified in a yeast two-hybrid screen as a Bcl-xL interacting protein. It also interacts with other anti-apoptotic family members, including Bcl-2, but fails to interact with pro-apopotic proteins Bax and Bak. Aven inhibits apoptosis and enhances anti-apopotic activity of Bcl-xL. It interferes with association with Apaf-1 and activation of caspase-9. Aven overexpression is associated with poor prognosis in acute lymphoblastic leukemia.
Catalog #A4445-11D
ApplicationsSuitable for use in Immunofluorescence, Flow Cytometry, ELISA and Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1:1000
Immunofluorescence (IF-IC): 1:50
Flow Cytometry: 1:200
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
ConcentrationNot Determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
PurityPurified by Protein A affinity chromatography
ImmunogenSynthetic peptide corresponding to residues at the carboxy terminus of Aven
SpecificityDetects endogenous levels of total Aven protein. Species Crossreactivity: human, monkey, mouse and rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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