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Abs to Apoptosis, Caspase
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Anti -Aven (Apoptosis Caspase Activation Inhibitor, Cell Death Regulator Aven, PDCD12)
Anti -Aven (Apoptosis Caspase Activation Inhibitor, Cell Death Regulator Aven, PDCD12)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B FC IF |
|
| The Bcl-2 family regulates apoptosis in response to a wide range of stimuli through control of mitochondrial cytochrome c release and caspase activation. Cytosolic Apaf-1 forms a complex with caspase-9 in the presence of cytochrome c and dATP, ultimately leading to caspase-9 activation and subsequent activation of caspase-3. A large number of proteins have been found to interact with Bcl-2 and other family members that have been shown to help regulate apoptosis. Aven was identified in a yeast two-hybrid screen as a Bcl-xL interacting protein. It also interacts with other anti-apoptotic family members, including Bcl-2, but fails to interact with pro-apopotic proteins Bax and Bak. Aven inhibits apoptosis and enhances anti-apopotic activity of Bcl-xL. It interferes with association with Apaf-1 and activation of caspase-9. Aven overexpression is associated with poor prognosis in acute lymphoblastic leukemia. | | | Catalog # | A4445-11D | | Applications | Suitable for use in Immunofluorescence, Flow Cytometry, ELISA and Western Blot. Other applications not tested. | | Recommended Dilutions | Western Blot: 1:1000 | | Immunofluorescence (IF-IC): 1:50 | | Flow Cytometry: 1:200 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Concentration | Not Determined | | Form | Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. | | Purity | Purified by Protein A affinity chromatography | | Immunogen | Synthetic peptide corresponding to residues at the carboxy terminus of Aven | | Specificity | Detects endogenous levels of total Aven protein. Species Crossreactivity: human, monkey, mouse and rat | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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