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Abs to Apoptosis, Caspase
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Anti -Aven (Apoptosis Caspase Activation Inhibitor, Cell Death Regulator Aven, PDCD12)
Anti -Aven (Apoptosis Caspase Activation Inhibitor, Cell Death Regulator Aven, PDCD12)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B |
|
| PDCD12 (Programmed cell death 12), also referred to as AVEN, represents a new class of cell death regulator. PDCD12 is a conserved intracellular membrane protein that blocks apoptosis impeded by Apaf-1 mediated caspase activation. Bcl-2 and BAD also interact with PDCD12 to prevent apoptosis. It is expressed in a wide variety of normal tissues including heart, skeletal muscle, kidney, liver, testis, and diseases such as cancer | | | Applications: | | | Suitable for use in ELISA and Western Blot Other applications not tested. | | | Catalog # | A4445-11L | | Recommended Dilution | Western Blot: 1:1000-3000 | | Optimal dilutions to be determined by the researcher. | | Hybridoma | Hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PDCD12 protein. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a,k | | Clone No | 9C85 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant human PDCD12 (254-362aa) purified from E. coli | | Specificity | Recognizes human PDCD12 (Programmed cell death 12, AVEN). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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