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You are here:Home » Antibodies » Abs to Wnt Proteins » Anti -Axin 1 (Axis Inhibitor 1, MGC52315)

Anti -Axin 1 (Axis Inhibitor 1, MGC52315)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
Axin, an important regulator of beta-catenin, is frequently mutated in human hepatocellular carcinomas (HCCs), and transduction of the wild-type Axin gene (AXIN1) induces apoptosis in HCC cells as well as in colon cancer cells. A novel gene, AXUD1 (AXIN 1 up-regulated), has enhanced expression in response to exogenously expressed AXIN1. It is expressed in all human tissues examined, most abundantly in lung, placenta, skeletal muscle, pancreas and leukocytes.
Catalog #A4747
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:32,000.
Western Blot: No signal obtained yet but low background observed in Human Brain, Human Pancreas, MOLT-4 and HeLa lysates at up to 2.0ug/ml.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified from goat serum by ammonium sulfate precipitation followed by immunoaffinity chromatography.
ImmunogenPeptide with sequence FEEKIIGKVEKVD, from C Terminus of the protein sequence according to NP_003493; NP_851393.
SpecificityRecognizes AXIN 1. Species Crossreactivity: Expected to crossreact with Human, Mouse and Rat due to sequence homology.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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