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You are here:Home » Antibodies » Antibodies-Wnt Proteins » Anti -Axin (Axis Ihibition Protein)

Anti -Axin (Axis Ihibition Protein)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
The Axin (axis inhibition) protein is an ~120-130kD negative regulator of Wnt pathway signaling. The Wnt pathway is essential for embryonic axis development in amphibians, Drosophila, and mammals; Axin has been shown to inhibit dorsal axial development. In vertebrates, Wnt signaling occurs when the frizzled receptor transduces a signal to the Dishevelled protein, triggering glycogen synthase kinase-3 (GSK-3) inactivation and the accumulation of b-catenin. Axin binds directly to GSK-3b, b-catenin, and the adenomatous polyposis coli (APC) tumor suppressor protein at separate binding sites; these four proteins form a tetrameric complex that regulates b-catenin stability and signaling.
Catalog #A4747A
ApplicationsSuitable for use in Western Blot. Other applications have not been tested.
Recommended DilutionWestern Blot: 0.1-2.0ug/ml. Detects a band at ~120-130kD using Jurkat leukemia T cell lysates.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide derived from the internal region of the human Axin protein. Based on amino acid sequence, this antibody is not expected to cross-react with Axin-2.
SpecificityRecognizes human Axin. On Western blots, it recognizes a doublet band at ~120-130kD. Species sequence homology: mouse, rat, and chicken-86%.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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