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5-Azacytidine (Azacitidine, 4-Amino-1-B-D-ribofuranosyl-1,3,5-triazin-2(1H)-one, 5-AzaC, Ladakamycin)
5-Azacytidine (Azacitidine, 4-Amino-1-B-D-ribofuranosyl-1,3,5-triazin-2(1H)-one, 5-AzaC,
Ladakamycin)
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| A potent growth inhibitor and cytotoxic agent; a potent DNA methyltransferase inhibitor. Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to DNA and reactivate tumor suppressor genes. Also recently shown to increase reprogramming efficiency of stem cells 10-fold. | | | Catalog # | A4933-02 | | Solubility | AcOH: H2O (1:1) (5mg/ml) | | Molecular Weight | ~244.2 | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with AcOH. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | 320-67-2 | | Molecular Formula | C H N O | | Molecular Weight | ~244.2 | | Purity | ~98% (TLC) | | Form | Supplied as a white to off-white solid. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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