Anti -B7H4 (B7-H4, B7S1, B7x, BC032925, Immune Costimulatory Protein B7H4, MGC41287,
PRO1291, T Cell Costimulatory Molecule B7x, V Set Domain-containing T Cell Activation
Inhibitor 1, VCTN1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IP IH IC |
|
| As a member of B7 family, B7-H4 (VTCN1) plays a critical role in the regulation of antigen-specific immune responses.B7-H4 is a co-stimulatory protein expressed in activated T cells and is involved in the negative regulation of cell-mediated immunity in peripheral tissues (1). B7-H4 ligation to its receptor BTLA T-lymphocytes results in inhibition of T-cell activation, cytokine secretion, and the development of cytotoxicity (2).B7-H4 protein is typically expressed on the surface of activated T-cells, B-cells, monocytes, and dendritic cells, but not in most normal | | | tissues.In tissues, B7-H4 is over expressed in breast, endometrial, ovarian, renal cell (RCC), and non-small cell lung carcinomas (NSCLC).B7-H4 has been identified as an important cancer marker for breast and ovarian cancers (3). | | | | | | Applications: | | | Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested. | | | Catalog # | B0000-35 | | Recommended Dilutions | Western Blot (Human, mouse and rat): 1:1000-1:10,000 | | Immunoprecipitation (Human): 1:20 | | Immunohistochemistry (Human and mouse): 1:250-1:500 | | Immunocytochemistry (Human): 1:100-1:250 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human tonsil | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9H294 | | Host | Rabbit | | Source | Human | | Concentration | Not Determined | | Form | Supplied as a liquid in 49% PBS, 0.01% sodium azide, 0.05% BSA, 50% glycerol. | | Purity | Supernatant | | Immunogen | Peptide corresponding to residues near the N-terminal of human B7H4. | | Specificity | Recognizes human B7H4 at ~50kD. Species Crossreactivity: rat and mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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