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You are here:Home » Antibodies » Abs to T Cells » Anti -B7H4 (B7-H4, B7S1, B7x, BC032925, Immune Costimulatory Protein B7H4, MGC41287, PRO1291, T Cell Costimulatory Molecule B7x, V Set Domain-containing T Cell Activation Inhibitor 1, VCTN1)

Anti -B7H4 (B7-H4, B7S1, B7x, BC032925, Immune Costimulatory Protein B7H4, MGC41287,
PRO1291, T Cell Costimulatory Molecule B7x, V Set Domain-containing T Cell Activation
Inhibitor 1, VCTN1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
As a member of B7 family, B7-H4 (VTCN1) plays a critical role in the regulation of antigen-specific immune responses. B7-H4 is a co-stimulatory protein expressed in activated T cells and is involved in the negative regulation of cell-mediated immunity in peripheral tissues. B7-H4 ligation to its receptor BTLA T-lymphocytes results in inhibition of T-cell activation, cytokine secretion, and the development of cytotoxicity. B7-H4 protein is typically expressed on the surface of activated T-cells, B-cells, monocytes, and dendritic cells, but not in most normal tissues. In tissues, B7-H4 is over expressed in breast, endometrial, ovarian, renal cell (RCC), and non-small cell lung carcinomas (NSCLC). B7-H4 has been identified as an important cancer marker for breast and ovarian cancers.
Catalog #B0000-35A
ApplicationsSuitable for use in Peptide ELISA and Western Blot. Other applications not tested.
Recommended DilutionsPeptide ELISA: 1:64,000 (Detection limit dilution)
Western Blot: 0.5-1.5ug/ml. Detects an ~28kD band in human pancreas lysates.
Optimal dilutions to be determined by the researcher.
Control PeptideB0000-35A-P
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-SKGKGNANLEYK, from the internal region of human B7H4 (NP_078902.2). Species Sequence Homology: mouse, rat, canine.
SpecificityRecognizes human B7H4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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