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Anti -BACE, Asp2 (CT) (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2)
Anti -BACE, Asp2 (CT) (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Highly Purified |
B |
|
| Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b-and g-sites by two proteases. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4kD amyloid-b peptide, which is deposited in the brains of all suffers of Alzheimer’s disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. | | | Catalog # | B0002-90 | | This antibody can be used for detection of BACE by Western blot at 0.5 to 1ug/ml. Human brain tissue lysate can be used as positive control and an approximately 70kD band should be detected. It is human and mouse reactive | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | 0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Supplied as chromatographically purified IgG | | Immunogen | Peptide corresponding to amino acids 485 to 501 of human BACE (1). | | Specificity | Recognizes human and mouse BACE/Asp2 (CT) | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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