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You are here:Home » Antibodies » Abs to Apoptosis » Anti -BACE, Asp2 (CT) (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2)

Anti -BACE, Asp2 (CT) (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Highly Purified B
Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b-and g-sites by two proteases. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4kD amyloid-b peptide, which is deposited in the brains of all suffers of Alzheimer’s disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP.
Catalog #B0002-90
This antibody can be used for detection of BACE by Western blot at 0.5 to 1ug/ml. Human brain tissue lysate can be used as positive control and an approximately 70kD band should be detected. It is human and mouse reactive
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PuritySupplied as chromatographically purified IgG
ImmunogenPeptide corresponding to amino acids 485 to 501 of human BACE (1).
SpecificityRecognizes human and mouse BACE/Asp2 (CT)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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