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You are here:Home » Antibodies » Abs to Apoptosis » Anti -BACE, CT (Beta-secretase 1, Beta-site APP Cleaving Enzyme 1, Beta-site Amyloid Precursor Protein Cleaving Enzyme 1, Aspartyl Protease 2, Asp 2, ASP2, Membrane-associated Aspartic Protease 2, Memapsin-2, BACE1, BACE, KIAA1149)

Anti -BACE, CT (Beta-secretase 1, Beta-site APP Cleaving Enzyme 1, Beta-site Amyloid
Precursor Protein Cleaving Enzyme 1, Aspartyl Protease 2, Asp 2, ASP2, Membrane-associated
Aspartic Protease 2, Memapsin-2, BACE1, BACE, KIAA1149)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Highly Purified B IC
Accumulation of the amyloid-beta (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b- and g-sites by two proteases. APP is first cleaved by beta secretase, producing a soluble derivative of the protein and a membrane anchored 99aa C-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4kD amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
Catalog #B0002-90Q
ApplicationsSuitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml
Immunocytochemistry: 10ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman brain tissue lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
PurityPurified by Ion Exchange chromatography.
ImmunogenSynthetic peptide corresponding to 17aa at the C-terminus of human BACE.
SpecificityRecognizes human BACE. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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