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You are here:Home » Antibodies » Antibodies-Apoptosis » Anti -BACE1 (Beta-site APP Cleaving Enzyme)

Anti -BACE1 (Beta-site APP Cleaving Enzyme)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Beta site APP cleaving enzyme (BACE1), also identified as b secretase, is an aspartyl protease. The mature form of the enzyme is an N-glycosylated integral membrane protein with Mr=70kD. The N-glycosylation and carbohydrate trimming of immature BACE1 are observed to take place within the Golgi apparatus. BACE1 cleaves Amyloid Precursor Protein (APP), generating two fragments, the APP N terminal fragment (APPsb) with Mr=100kD and a smaller C-terminal fragment with Mr=12kD (C99). Subsequent cleavage of the smaller fragment by g-secretase produces b-amyloid (Ab). Improperly regulated production of b-amyloid leads to deposition of amyloid plaques found in Alzheimer’s disease, a neurodegenerative, dementia-inducing disorder.
Catalog #B0002-91
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.25-1.0ug/ml
Optimal dilutions to be determined by the researcher.
Recommended Positive ControlSH-SY5Y neuroblastoma cell lysate.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.2, 1% BSA, 0.1% sodium azide, before the addition of glycerol to 40%.
PurityPurified by protein A/G affinity chromatography.
ImmunogenSolubilized total recombinant protein.
SpecificityRecognizes human BACE1. Crossreactivity with BACE2 is almost negligible.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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