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Anti -BACE1 (Beta-site APP Cleaving Enzyme)
Anti -BACE1 (Beta-site APP Cleaving Enzyme)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IH |
|
| Beta site APP cleaving enzyme (BACE1), also identified as b secretase, is an aspartyl protease. The mature form of the enzyme is an N-glycosylated integral membrane protein with Mr=70kD. The N-glycosylation and carbohydrate trimming of immature BACE1 are observed to take place within the Golgi apparatus. BACE1 cleaves Amyloid Precursor Protein (APP), generating two fragments, the APP N terminal fragment (APPsb) with Mr=100kD and a smaller C-terminal fragment with Mr=12kD (C99). Subsequent cleavage of the smaller fragment by g-secretase produces b-amyloid (Ab). Improperly regulated production of b-amyloid leads to deposition of amyloid plaques found in Alzheimer’s disease, a neurodegenerative, dementia-inducing disorder. | | | Catalog # | B0002-91T | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.1% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to human BACE1 at N-terminal (KLH). | | Specificity | Recognizes human BACE1. Species sequence homology: Mouse (22/44%) and rat (22/44%). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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