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You are here:Home » Antibodies » Antibodies-Apoptosis » Anti -BACE1 (Beta-site APP Cleaving Enzyme)

Anti -BACE1 (Beta-site APP Cleaving Enzyme)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Beta site APP cleaving enzyme (BACE1), also identified as b secretase, is an aspartyl protease. The mature form of the enzyme is an N-glycosylated integral membrane protein with Mr=70kD. The N-glycosylation and carbohydrate trimming of immature BACE1 are observed to take place within the Golgi apparatus. BACE1 cleaves Amyloid Precursor Protein (APP), generating two fragments, the APP N terminal fragment (APPsb) with Mr=100kD and a smaller C-terminal fragment with Mr=12kD (C99). Subsequent cleavage of the smaller fragment by g-secretase produces b-amyloid (Ab). Improperly regulated production of b-amyloid leads to deposition of amyloid plaques found in Alzheimer’s disease, a neurodegenerative, dementia-inducing disorder.
Catalog #B0002-91T
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human BACE1 at N-terminal (KLH).
SpecificityRecognizes human BACE1. Species sequence homology: Mouse (22/44%) and rat (22/44%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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