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You are here:Home » Antibodies » Abs to Apoptosis » Anti -BACE2 (Beta-secretase 2, Beta-site Amyloid Precursor Protein Cleaving Enzyme 2, Beta-site APP Cleaving Enzyme 2, Aspartyl Protease 1, Asp 1, ASP1, Membrane-associated Aspartic Protease 1, Memapsin-1, Aspartic-like Protease 56kD, Down Region Aspartic Prote

Anti -BACE2 (Beta-secretase 2, Beta-site Amyloid Precursor Protein Cleaving Enzyme 2,
Beta-site APP Cleaving Enzyme 2, Aspartyl Protease 1, Asp 1, ASP1, Membrane-associated
Aspartic Protease 1, Memapsin-1, Aspartic-like Protease 56kD, Down Region Aspartic Prote

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B IH
Amyloid-beta peptide aggregation is a signature of Alzheimer disease and a frequent complication of adult Down syndrome patients. Amyloid-beta is generated by proteolytic processing of the amyloid precursor protein (APP) by beta- and gamma-secretase at the N and C termini, respectively. Presenilin-1 is involved in the gamma-secretase activity. BACE is a transmembrane aspartyl protease with beta-secretase activity. BACE2, also termed ALP56 has 2 pepsin-like active centers, a signal sequence, a propeptide, and a long C-terminal extension including a transmembrane domain, with expression in a wide array of tissues. Northern blot analysis revealed low expression of 2 and 2.6kb BACE2 transcripts in most fetal and adult tissues, with higher expression in adult colon, kidney, pancreas, placenta, prostate, stomach, and trachea. Low levels were also detected in brain, with somewhat higher expression in medulla and spinal cord. In situ hybridization analysis of rat brain found low-level BACE2 expression in contrast to BACE expression. The BACE2 expression pattern does not appear to be consistent with that of a beta-secretase. BACE2 has been mapped to 21q22.3, within the Down syndrome critical region.
Catalog #B0002-92G
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 20ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified
ImmunogenSynthetic peptide corresponding to aa44-59 of human BACE2 (KLH).
SpecificityRecognizes human BACE2. Species sequence homology: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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