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You are here:Home » Antibodies » Abs to Apoptosis » Anti -BACE2, Asp1 (CT) (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2, DRAP, Down Region Aspartic Protease, Memapsin)

Anti -BACE2, Asp1 (CT) (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2, DRAP, Down
Region Aspartic Protease, Memapsin)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b-and g-sites by proteases. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1–4). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4–9). BACE2 also cleaves APP at b-site and at a different site within Ab (8). BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and Ab may also contribute to the pathogenesis of Down syndrome (6,7)
Catalog #B0003-01
ApplicationsSuitable for use in ELISA, Western Blotting. Other applications not tested.
Recommended DilutionWestern Blotting: 0.5-1ug/ml.
Optimal dilutions to be determined by the researcher.
Positive Control Human heart tissue lysate can be used as positive control.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid, 100ug in 200ul of PBS, 0.02% sodium azide.
PurityImmunoaffinity chromatography purified IgG
ImmunogenRaised against a peptide corresponding to amino acids 496 to 511 of human BACE2 (4).
SpecificityRecognizes human BACE2. Species crossreactivity: Mouse and rat.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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