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You are here:Home » Antibodies » Abs to Apoptosis » Anti -BACE2, CT (Beta-secretase 2, Aspartic-like Protease 56kD, Aspartyl Protease 1, ASP1, Asp 1, Beta-site Amyloid Precursor Protein Cleaving Enzyme 2, Beta-site APP Cleaving Enzyme 2, Down Region Aspartic Protease, DRAP, Memapsin-1, Membrane-associated Aspart

Anti -BACE2, CT (Beta-secretase 2, Aspartic-like Protease 56kD, Aspartyl Protease 1, ASP1,
Asp 1, Beta-site Amyloid Precursor Protein Cleaving Enzyme 2, Beta-site APP Cleaving
Enzyme 2, Down Region Aspartic Protease, DRAP, Memapsin-1, Membrane-associated Aspart

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b- and g-sites by proteases. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at b-site and at a different site within Ab. BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and Ab may also contribute to the pathogenesis of Down syndrome.
Catalog #B0003-01D
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aas near the C-terminus of human BACE2 conjugated to KLH.
SpecificityRecognizes human BACE2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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