Anti -BACE2, NT (Beta-secretase 2, Aspartic-like Protease 56kD, Aspartyl Protease 1, ASP1,
Asp 1, Beta-site Amyloid Precursor Protein Cleaving Enzyme 2, Beta-site APP Cleaving
Enzyme 2, Down Region Aspartic Protease, DRAP, Memapsin-1, Membrane-associated Aspart
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B IH |
|
| Accumulation of the amyloid-beta (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. A-beta peptide is generated by proteolytic cleavage of the beta amyloid protein precursor (APP) at b- and g-sites by proteases.The long-sought beta secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Ab. BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and Ab may also contribute to the pathogenesis of Down syndrome. | | | Catalog # | B0003-01F | | Applications | Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-1ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human heart tissue lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa near the N-terminus of human BACE2. | | Specificity | Recognizes human BACE2. Species Crossreactivity: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -BACE2, NT (Beta-secretase 2, Aspartic-like Protease 56kD, Aspartyl Protease 1, ASP1, Asp 1, Beta-site Amyloid Precursor Protein Cleaving Enzyme 2, Beta-site APP Cleaving Enzyme 2, Down Region Aspartic Protease, DRAP, Memapsin-1, Membrane-associated Aspart |
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