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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -BAFF (B cell Activating Factor belonging to TNF Family, BLyS, TALL-1, THANK)

Anti -BAFF (B cell Activating Factor belonging to TNF Family, BLyS, TALL-1, THANK)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF-and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell stimulator since it induced B cell proliferation and immunoglobulin secretion. Two receptors for BAFF were recently identified and designated TACI and BCMA (5). BAFF and its receptors are involved in the development of systemic lupus erythaematosus and other B cell associated autoimmune diseases. Like TNFa and TRAIL, THANK was shown to activate NF-kB and c-jun N-terminal kinase (JNK) and to induce apoptosis.
Catalog #B0003-64R
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.5ug/ml using 100ul/well. Allows the detection of 0.2-0.4ng/well.
Western Blot: 0.1- 0.2ug/ml. The detection limit is 1.5-3.0ng/lane, under either reducing or non-reducing conditions.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by immunoaffinity chromatography.
ImmunogenHighly pure (> 98%) recombinant human BAFF
SpecificityRecognizes human BAFF.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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