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You are here:Home » Growth Factors, Cytokines » Growth Factors-BAFF » BAFF, CT, Blocking Peptide (B cell Activating Factor belonging to TNF Family, BLyS, TALL-1, THANK)

BAFF, CT, Blocking Peptide (B cell Activating Factor belonging to TNF Family, BLyS,
TALL-1, THANK)

Pricing

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Specifications

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF-and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell stimulator since it induced B cell proliferation and immunoglobulin secretion. Two receptors for BAFF were recently identified and designated TACI and BCMA. BAFF and its receptors are involved in the development of systemic lupus erythaematosus and other B cell associated autoimmune diseases. Like TNFa and TRAIL, THANK was shown to activate NF-kB and c-jun N-terminal kinase (JNK) and to induce apoptosis.
Catalog #B0003-65P
ApplicationsSuitable for use in Antibody Blocking. Other applications not tested.
Recommended DIlutionsAntibody Blocking: To block the antibody activity completely, incubate B0003-65P with equal volume of B0003-65.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourcePeptide corresponding to aa254 to 269 of human BAFF.
PurityPurified
Concentration~0.2mg/ml
FormSupplied as a liquid in PBS pH 7.2, 0.1% BSA, 0.02% sodium azide
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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