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You are here:Home » Growth Factors, Cytokines » Growth Factors-BAFF » BAFF Receptor, Control Peptide (BAFF-R, BR3, BLyS Receptor 3)

BAFF Receptor, Control Peptide (BAFF-R, BR3, BLyS Receptor 3)

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Specifications

Blocking peptide for B0003-68.
Catalog #B0003-68A
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4 (1- 4). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion (1,2). Two receptors, TACI and BCMA, for BAFF were originally identified (5). A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3 (6,7). Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-£eB and c-jun N-terminal kinase (4-6).
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: Incubating the peptide with equal volume of antibody (B0003-68) for 30 min at 37°C will usually completely block antibody activity.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceSynthetic peptide corresponding to aa169-183 of human BAFF-R
PurityPurified
Concentration~0.2mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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