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You are here:Home » Growth Factors, Cytokines » Growth Factors-BAFF » BAFF Receptor IgG2a Fc, Fusion Protein (BAFF-R, BR3, BLyS Receptor 3) (Preservative Free)

BAFF Receptor IgG2a Fc, Fusion Protein (BAFF-R, BR3, BLyS Receptor 3) (Preservative Free)

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Specifications

The human B cell activating factor (BAFF) and APRIL(a proliferation inducing ligand) are both type II molecules belonging to the TNF superfamily. They are expressed by non-B cells, and are down regulated by mitogenic stimulation(2). BAFF and APRIL bind to at least two receptors: TACI (transmembrane activator and CAML-interactor) and BCMA (B cell maturation antigen), both of which are restricted to B cells(3,4). Ligation of these receptors with recombinant BAFF dramatically increases IgM production by peripheral blood B cells(1). A third receptor for BAFF (BAFF-R) has been described(5). BAFF and BAFFR knockout mice have a reduced numbers of mature B cells in the periphery, however TACI and BCMA knockouts do not share this phenotype, suggesting that BAFF-R may the primary receptor for BAFF in mice(8,9,10). Cell surface BAFF can be proteolytically cleaved to form a soluble trimeric molecule(2). Levels of soluble BAFF correspond with levels of autoantibodies in Sjogren's Syndrome(11). Recombinant human BAFFR-muIg binds to recombinant BAFF-muCD8 and can inhibit binding of this molecule to receptors on Raji cells.
Catalog #B0003-68JX
Molecular Structure A soluble molecule consisting of the extracellular (60aa) domain of human BAFFR fused to the murine IgG2a Fc (232 aa). Predicted monomeric weight: 33. 5kD.
Transfectant Cell Line CHO
Functional Application BAFFR-muIg binds to recombinant BAFF-muCD8 and can inhibit this molecule's abiltiy to bind to receptors on Raji cells.
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight33.5kD
SourceCHO cells
PurityPurified by Protein A affinity chromatography.
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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