Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -BAFF (BlyS, THANK, TALL 1)

Anti -BAFF (BlyS, THANK, TALL 1)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B
Simultaneously four different laboratories identified a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 (1), THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase (2), BAFF (for B cell activating factor belonging to the TNF family) (3) and Blys (B lymphocyte stimulator) (4). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. Secreted Blys/BAFF/THANK acts as a potent B cell growth factor. This protein is expressed abundantly in peripheral blood lymphocytes, specifically in monocytes and macrophages. Its regulation is upregulated by interferon gamma. Overexpression of Blys/BAFF in transgenic mice lead to increased numbers of mature B and effector T cells. These mice also develop autoimmune –like symptoms, such as, high levels of rheumatoid factors, anti-DNA autoantibodies, etc. (5) Recently, two receptors for Blys/BAFF have been identified and termed as BCMA and TACI (6).
Catalog #B0003-69
ApplicationsSuitable for the detection of BLyS/BAFF expression in mouse and human cells by Western blot. Western blot analysis of BAFF/Blys in mouse and human cell lysates. Lane A: mouse testes, Lane B: mouse thymus, Lane C: mouse spleen, and Lane D: HL-60 cells (human).
Recommended DilutionWestern blot: 0.5-2ug/ml
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PurityPurified
ImmunogenC-terminal peptide corresponding to aa 254-269 of human BLyS.
SpecificityRecognizes human BAFF (BlyS, THANK, TALL 1)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links