You are here:Home
»
Antibodies
»
Abs to Cancer Markers
»
Anti -BAP1 (BRCA1 Associated Protein 1, Ubiquitin carboxyl-terminal hydrolase BAP1, EC 3.4.19.12, BRCA1-associated protein 1, Cerebral protein 6, BAP-1)
Anti -BAP1 (BRCA1 Associated Protein 1, Ubiquitin carboxyl-terminal hydrolase BAP1, EC
3.4.19.12, BRCA1-associated protein 1, Cerebral protein 6, BAP-1)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IC IF |
|
| Mutations within the BRCA1 gene, localized to chromosome 17q, are believed to account for approximately 45% of families with increased incidence of both early-onset breast cancer and ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. This protein contains a RING domain near the N-terminus and appears to encode a tumor suppressor. BARD1 (BRCA1-associated RING domain protein 1) and BAP1 (BRCA1-associated protein 1) have both been shown to bind to the N-terminus of BRCA1 and are potential mediators of tumor suppression. BARD1 contains an N-terminal RING domain and three tandem ankyrin repeats. The C-terminus of BARD1 contains a region with sequence homology to BRCA1, termed the BRCT domain. BAP1 is a ubiquitin hydrolase and has been shown to enhance BRCA1-mediated cell growth suppression. | | | Catalog # | B0076-12 | | Applications | Suitable for use in Western Blot, Immunocytochemistry and Immunofluorescence. Other applications not tested. | | Recommended Dilutions | Immunofluorescence (IC): 1:50-1:200 | | Western Blot: 2ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | HeLa whole cell lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1,k | | Clone No | 8B66 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in Tris-glycine, 150mM sodium chloride, 0.05% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Purified full-length human BAP1 expressed in E. coli. | | Epitope | Within the UCH domain of BAP1. | | Cellular Localization | Nuclear. | | Specificity | Recognizes human BAP1 at ~85kD. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
