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Specifications

Clone Host Grade Applications Monoclonal Mouse Purified E B IC IF

Bcl-2 (B-cell lymphoma protein 2 alpha) is an anti-apoptotic protein located primarily in the outer mitochondrial membrane. It blocks the apoptotic death of some cells such as lymphocytes. BCL-2 is thought to regulate cell death by controlling the mitochondrial membrane permeability during apoptosis. Bcl-2 protein has anti-apoptotic functions through inhibiting caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Catalog #	B0807-06K
Applications	Suitable for use in Immunofluorescence, ELISA, Western Blot, Immunocytochemistry. Other applications not tested.
Recommended Dilution	Immunofluorescence: 1:250 - 500
	Starting dilution: 1:500
	Optimal dilutions to be determined by the researcher.
Hybridoma	F0 myeloma cells with spleen cells from BALB/c mice.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG2b
Clone No	11H1
Host	Mouse
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
Purity	Purified
Immunogen	Recombinant corresponding to aa1-211 from human Bcl-2 expressed in E. coli.
Specificity	Recognizes human Bci-2.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.