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You are here:Home » Molecular Biology » MB-Apoptosis » BCMA IgG2a Fc, Fusion Protein (B Cell Maturation Protein) (Biotin)

BCMA IgG2a Fc, Fusion Protein (B Cell Maturation Protein) (Biotin)


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The human B cell activating factor (BAFF) and APRIL(a proliferation inducing ligand) are both type II molecules belonging to the TNF superfamily. They are expressed by non-B cells, and are down-regulated by mitogenic stimulation.2  BAFF and APRIL bind to at least two receptors: TACI (transmembrane activator and CAML-interactor) and BCMA (B cell maturation antigen), both of which are restricted to B cells.3,4  Ligation of these receptors with recombinant BAFF
dramatically increases IgM production by peripheral blood B cells 1.  Recently a third receptor  for BAFF (BAFF-R) was described.5  Cell surface BAFF can be cleaved to form a soluble trimeric molecule. 2BCMA-muIg binds to recombinant BAFF-muCD8 and can inhibit binding of this molecule to receptors on Raji cells.
Catalog #B0807-50C
Molecular Structure A soluble molecule consisting of the extracellular (54aa) domain of human BCMA fused  to the murine IgG2a Fc (232 aa).  Predicted monomeric weight: 33kD.
Transfectant Cell Line CHO 
Functional Application BCMA-muIg binds to recombinant BAFF-muCD8 and can inhibit this molecule's abiltiy to bind to receptors on Raji cells.
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight33kD
SourceCHO cells
PurityPurified by Protein A affinity chromatography.
FormSupplied as a liquid in PBS.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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