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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified E B

Antimicrobial peptides are a common mechanism of host defense utilized by a variety of species, from insects to humans. Defensins are a large family of broad-spectrum antimicrobial peptides, identified originally in leukocytes of rabbits and humans. Defensins, cationic/polar peptides (30-35 aa; 3-4kD), are distinguished by a conserved tri-disulfide and a largely b-sheet structure. Defensins, expressed at the cell surface, have been hypothesized to function as a biochemical barrier against microbial infection by inhibiting colonization of the epithelium by wide range of pathogenic microorganisms. In leukocytes, these peptides are stored in cytoplasmic granules and are released into phagolysosomes where they contribute to the killing of engulfed microorganisms.
Catalog #	B0899-03
Applications	Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilutions	ELISA: 0.5-1ug/ml, use control peptide to coat plates at 1ug/ml
	Western Blot: 1-10ug/ml (ECL.)
	Optimal dilutions to be determined by the researcher.
Control Peptide	B0900-09A: BD1, Control Peptide (beta Defensin-1)
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Mouse
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, pH 7.4, 0.1% BSA
Purity	Purified by immunoaffinity chromatography.
Immunogen	A synthetic peptide corresponding to 16aa near the N-terminus of mature mouse MBD-1, conjugated KLH. Species Sequence Homology: rat, 87%. No significant homology exists with human beta-defensin 1 or other defensins.
Specificity	Recognizes mouse BD-1.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.